In my opinion, Liverpool is a big favorite in this match. There are returning two excellent football players to the team, namely Steven Gerrard and Fernando Torres. For Wigan will be certainly most dangerous great Spaniard Torres, who will be a great threat to the hosts defensive players, and if that won't succeed him, the coach Rafe Benitez have also Dick Kuyt, Yossi Benayoun and the other boys, who are recently coming into increasingly better shape. Maybe there will not play Daniel Agger, meanwhile Fabio Aurelio is injured and lost for Liverpool at least until the end of the month.
Wigan is in the fight for survival. I don't think they will be able to obtain at least a draw result against Liverpool after two consecutive defeats in the championship. Coach Robert Martinez maybe won't be able to count on Charles N'Zogbia and Paul Scharner.
So victory on guests.

Last 6 matches Wigan Athletic:

27/02-10 Premier league: Birmingham vs. Wigan 1:0
21/02-10 Premier league: Wigan vs. Tottenham 0:3
17/02-10 Premier league: Wigan vs. Bolton 0:0
09/02-10 Premier league: Wigan vs. Stoke City 1:1
06/02-10 Premier league: Sunderland vs. Wigan 1:1
02/02-10 FA Cup: Wigan vs. Notts County 0:2

Last 6 matches Liverpool:

28/02-10 Premier league: Liverpool vs. Blackburn 2:1
25/02-10 UEFA Europa League: Europa Unirea Urziceni vs. Liverpool 1:3
21/02-10 Premier league: Manchester City vs. Liverpool 0:0
18/02-10 UEFA Europa League: Liverpool vs. Unirea Urziceni 1:0
10/02-10 Premier league: Arsenal vs. Liverpool 1:0
06/02-10 Premier league: Liverpool vs. Everton 1:0

Over/under goal statistics:

Wigan Athletic season 2009/2010:
Over 2.5 Goals: 14 (52%)
Under 2.5 Goals: 13 (48%)

Liverpool season 2009/2010:
Over 2.5 Goals: 13 (46%)
Under 2.5 Goals: 15 (54%)

History:
16/12-09 Premier league: Liverpool vs. Wigan 2:1
28/01-09 Premier league: Wigan vs. Liverpool 1:1
18/10-08 Premier league: Liverpool vs. Wigan 3:2
02/01-08 Premier league: Liverpool vs. Wigan 1:1
29/09-07 Premier league: Wigan vs. Liverpool 0:1
21/04-07 Premier league: Liverpool vs. Wigan 2:0
02/12-06 Premier league: Wigan vs. Liverpool 0:4
11/02-06 Premier league: Wigan vs. Liverpool 0:1
03/12-05 Premier league: Liverpool vs. Wigan 3:0

My tip is 2
Highest odd is on betsson 1,62